Clinical Medicine Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of clinical medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Objective: To evaluate the safety and efficacy of Contactive chemolysis through sacral hiatus (CCTSH) in the treatment of free lumbar disc herniation. Methods: A prospective randomized controlled clinical trial was designed. According to the inclusion criteria, 20 patients in the study group were treated with CCTSH, and 20 patients in the control group were treated with Chemical lysis through the sacral hiatus. The complications such as puncture site infection, chemical cerebrospinal meningitis, cauda equina injury, contrast medium allergy and so on were recorded. The pain index (VAS) was compared before operation, 24 hours and 72 hours after operation, The spinal dysfunction index (ODI) was compared before operation, 3 days and 3 months after operation, and the size of prolapse was compared on CT/MRI before operation and 3 months after operation. Results: All the 40 patients in the two groups were successfully operated without serious complications, and one patient in the control group was lost to follow-up. The VAS scores of the two groups showed a downward trend before treatment, 24 h and 72 h after treatment, and the difference was statistically significant (P < 0.05); there was no difference between the two groups before treatment, 24 h after treatment (P > 0.05), and there was a significant difference between the two groups 72 h after treatment (P < 0.05); Before treatment, 3 days and 3 months after treatment, the ODI of the two groups decreased gradually, and the difference was statistically significant (P < 0.05), There was no difference between the two groups before treatment (P > 0.05), but there was significant difference between the two groups after treatment (P < 0.05); the prolapse in CT/MRI images of the two groups before and 3 months after the operation was significantly smaller, and the difference was statistically significant (P < 0.05), There was no difference between the two groups before the treatment (P > 0.05), but there was significant difference between the two groups after the treatment (P < 0.05). Conclusion: CCTSH is a safe, effective and minimally invasive method for the treatment of free lumbar disc herniation.Abstract: Objective: To evaluate the safety and efficacy of Contactive chemolysis through sacral hiatus (CCTSH) in the treatment of free lumbar disc herniation. Methods: A prospective randomized controlled clinical trial was designed. According to the inclusion criteria, 20 patients in the study group were treated with CCTSH, and 20 patients in the control g...Learn More
Abstract: Urticaria is a common allergic disease in dermatology outpatient clinics with an incidence rate of about 5%, clinically characterized mainly by sudden itching Previous studies have found that transient receptor potential (TRP) ion channels are named after the transient rather than sustained peak potentials generated by the body in response to internal and external stimuli. They play key role in the pathogenesis of urticaria. TRP is an important class of non-selective cation channels located on the cell membrane. These channels are affected by cold and heat, stimuli, inflammatory mediators, oxidative stress, osmotic pressure, and pH changes, and they exert various pathophysiological functions by integrating multiple stimuli and transducing their activity to downstream cell signaling pathways Ca2+ influx (or) membrane depolarization. TRP channels are mainly activated by G protein-coupled receptors, ligands, temperature, and osmotic pressure, and are involved in the and development of urticaria. Studies have found that TRPV, TRPA1, TRPC, and TRPM are involved in the pathological process of urticaria and the conduction of itching. In clinical practice, by regulating the sensitivity of TRP channels, the "itch-scratch-rash vicious cycle" of urticaria can often be blocked. This article aims to the research progress on the relationship between TRP channels and urticaria, and explore new therapeutic strategies targeting TRP channels, providing a new theoretical basis for the clinical prevention and treatment oficaria.Abstract: Urticaria is a common allergic disease in dermatology outpatient clinics with an incidence rate of about 5%, clinically characterized mainly by sudden itching Previous studies have found that transient receptor potential (TRP) ion channels are named after the transient rather than sustained peak potentials generated by the body in response to inter...Learn More
